We use polymer-based technology that makes new formulation development simple, scalable and affordable.
The OCL-Platform is a thermo-reversible hydrogel and consists of bio-erodable polymers, that are safe, easy to scale-up and easy to formulate with very different types of drugs:
- small molecule drugs, peptides, hormones, proteins and anti-bodies
- from poorly soluble to highly soluble
- with Molecular weights from 100D to 5kD
- and loading from 0.01% up to 5% drug weight/volume
One major USP is the fact that we use raw materials which are well-known, readily available off the shelf at Pharma grade. Our formula has several base patents pending while we prepare for new patents in the coming years.
A second major USP is that making of the product formulation is basically no more than standard compounding of the drugs and the excipients in an aqueous solvent. Any CMO with capacity to compound injectables can be commissioned to produce the products under licenses.
The OCL-formulations are easily injected through long needles (up to 25G) or catheters (5 French, up to 1 meter) in any location. Upon injection, the formulation rapidly forms a stable matrix, resulting in the localized drug depot ‘in situ – in seconds’. As the depot degrades, the stored drugs are slowly released into the surrounding tumor.
The OCL-platform has been developed for localized and slow release of different drugs in tumors at different locations, using different methods of injection.
The depots are imageable on CT and Ultra Sound, which will benefit image-guided delivery through endoscopes or stereo-tactic delivery
OncoLize will develop the OCL-platform for all types of tumor diseases. We have selected a range of suitable oncology drugs, both generic and novel.
These are formulated by OncoLize as oncology products for slow, localized delivery in solid tumors. Together with our partners we will develop a pipeline of products for some of the most deadly tumor diseases.
Technology licenses for external development can be made available for selected Product-Market Combinations.